Date Time
Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis
Researchers at The University of Texas MD Anderson Cancer Center have discovered that mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, interact through the CREB1 protein to promote metastasis and tumor growth. Blocking CREB1 in preclinical models reversed these effects and reduced metastases, suggesting an important new therapeutic target for the deadly cancer.
“To our knowledge, this is the first study to show how these two major genetic drivers work together to promote tumor growth and metastasis,” Kim said. “We learned that signaling downstream of mutant KRAS directly promotes mutant p53 activity. This discovery provides not only a new therapeutic target but unveils a vast transcriptional network that is activated downstream of these mutant proteins.”
Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas
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Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis
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Mayo Clinic doctors raise awareness for National minority health month
Mayo medical professionals say the health care workforce has seen issues of systemic social injustice and racism across many generations.
Posted: Apr 9, 2021 9:48 AM
Posted By: Samantha Soto
ROCHESTER, Minn. - April is National Minority Health Month. To raise awareness, Mayo Clinic doctors held a media briefing to discuss health disparities among people of color.
Mayo medical professionals say the health care workforce has seen issues of systemic social injustice and racism across many generations.
The pandemic has only helped to expose even more disparities in communities of color.
Though the health care workforce is ever changing, there is an underrepresented amount of people of color in the healthcare field.